4-Methylphenyl isocyanate → HCID 15053504, compound

HRID 2107247Notes

Reaction equation

HRID 2107247 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[C:14]1([CH3:23])[CH:19]=[CH:18][C:17]([N:20]=[C:21]=[O:22])=[CH:16][CH:15]=1>CN(C)C=O>[C:14]1([CH3:23])[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:22])[NH:1][C:2]2[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 693254-Methylphenyl isocyanateHCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 15053504HCID 15053504, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following a procedure similar to that described in Preparation 1. the desired compound was prepared from 12 g of ethyl 2-aminothiazol-4-ylglyoxylate. 10 g of p-tolyl isocyanate and 80 ml of dimethylformamide. The resulting product was a yellow powder having the following physical properties.

Workup

  1. customthat described in Preparation 1

Sources & evidence

ORD record
ord-0c6716fa7822472dbd498a9777338a4f
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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