Benzene, 1-isocyanato-4-nitro- → Ethyl 2-(3-p-nitrophenylureido)thiazol-4-ylglyoxylate

HRID 2107249Notes

Reaction equation

HRID 2107249 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[N+:14]([C:17]1[CH:22]=[CH:21][C:20]([N:23]=[C:24]=[O:25])=[CH:19][CH:18]=1)([O-:16])=[O:15]>CN(C)C=O>[N+:14]([C:17]1[CH:18]=[CH:19][C:20]([NH:23][C:24](=[O:25])[NH:1][C:2]2[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)=[CH:21][CH:22]=1)([O-:16])=[O:15]

Participants

4

Reactant 2

HCID 66012Benzene, 1-isocyanato-4-nitro-HCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 15053506Ethyl 2-(3-p-nitrophenylureido)thiazol-4-ylglyoxylate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following a procedure similar to that described in Preparation 1, the desired compound was prepared from 4.88 g of ethyl 2-aminothiazol-4-ylglyoxylate, 5 g of p-nitrophenyl isocyanate and 30 ml of dimethylformamide. The resulting product was a pale yellow powder having the following physical properties.

Workup

  1. customthat described in Preparation 1

Sources & evidence

ORD record
ord-97559484d2e14ed49ade724612f3d0cd
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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