Methyl Isocyanate → HCID 15053518, compound

HRID 2107251Notes

Reaction equation

HRID 2107251 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH3:14][N:15]=[C:16]=[O:17]>C(OCC)(=O)C>[CH3:14][NH:15][C:16](=[O:17])[NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 15053518HCID 15053518, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Following a procedure similar to that described in Preparation 1, the desired compound was prepared from 10 g of ethyl 2-aminothiazol-4-ylglyoxylate. 7 g of methyl isocyanate and 200 ml of ethyl acetate. The resulting product was a pale yellow powder having the following physical properties.

Workup

  1. customthat described in Preparation 1

Sources & evidence

ORD record
ord-1c98cb30176f44b2b93fec59429de482
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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