2-Fluorophenyl isothiocyanate → HCID 15053509, compound

HRID 2107257Notes

Reaction equation

HRID 2107257 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[F:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]=[C:22]=[S:23]>CN(C)P(=O)(N(C)C)N(C)C>[F:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[NH:21][C:22](=[S:23])[NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 975202-Fluorophenyl isothiocyanateHCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 15053509HCID 15053509, compound

Reagents, catalysts & solvents 1

HCID 12679HexamethylphosphoramideSolvent

Procedure

Following a procedure similar to that described in Preparation 1. the desired compound was prepared from 15 g of ethyl 2-aminothiazol-4-ylglyoxylate, 17 g of o-fluorophenyl isothiocyanate and 30 ml of hexamethylphosphoric triamide. The resulting product was a pale yellow powder having the following physical properties.

Workup

  1. customthat described in Preparation 1

Sources & evidence

ORD record
ord-70e4fd2e0e5b4b8dbd1fcbd16579eb02
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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