4-Fluorophenyl isothiocyanate → Ethyl 2-(3-p-fluorophenylthioureido)thiazol-4-ylglyoxylate

HRID 2107258Notes

Reaction equation

HRID 2107258 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[F:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]=[C:22]=[S:23])=[CH:17][CH:16]=1>CS(C)=O>[F:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[S:23])[NH:1][C:2]2[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 152414-Fluorophenyl isothiocyanateHCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 15053510Ethyl 2-(3-p-fluorophenylthioureido)thiazol-4-ylglyoxylate

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Following a procedure similar to that described in Preparation 1, the desired compound was prepared from 5 g of ethyl 2-aminothiazol-4-ylglyoxylate, 4.6 g of p-fluorophenyl isothiocyanate and 20 ml of dimethyl sulfoxide. The resulting product was a pale yellow powder having the following physical properties.

Workup

  1. customthat described in Preparation 1

Sources & evidence

ORD record
ord-09f912b3b7b148839ce974fd38c85d0f
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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