Ethyl 2-(phenylamino)-4-thiazolecarboxylate → HCID 15053553, compound

HRID 2107260Notes

Reaction equation

HRID 2107260 reaction equation
[NH:1]([C:8]1[S:9][CH:10]=[C:11]([C:13](OCC)=[O:14])[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH:1]([C:8]1[S:9][CH:10]=[C:11]([CH2:13][OH:14])[N:12]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 15053537Ethyl 2-(phenylamino)-4-thiazolecarboxylateHCID 21226445Aluminium lithium hydride

Product 1

HCID 15053553HCID 15053553, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Preparation 15, the desired compound was prepared from 8.5 g of ethyl 2-anilinothiazol-4-carboxylate, 2 g of lithium aluminum hydride and 150 ml of tetrahydrofuran, as colorless flakes having the following physical properties.

Workup

  1. customthat described in Preparation 15

Sources & evidence

ORD record
ord-709e174847f74fbd8903fb05c07ba5d1
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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