Triethylamine → HCID 15053525, compound

HRID 2107270Notes

Reaction equation

HRID 2107270 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:20])[NH:10][C:11]2[S:12][CH:13]=[C:14](/[CH:16]=[CH:17]/[CH2:18][OH:19])[N:15]=2)=[CH:4][CH:3]=1.C(N(CC)CC)C>CS(C)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:20])[NH:10][C:11]2[S:12][CH:13]=[C:14](/[CH:16]=[CH:17]/[CH:18]=[O:19])[N:15]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 15053524HCID 15053524, compound

Product 1

HCID 15053525HCID 15053525, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Following a procedure similar to that described in Preparation 49, the desired compound was prepared from 0.84 g of (E)-3-[2-(3-p-bromophenylureido)thiazol-4-yl]allyl alcohol, 1.13 g of a sulfur trioxide pyridine complex, 0.72 g of triethylamine and 20 ml of dimethyl sulfoxide. The resulting product was a pale brown powder having the following physical properties.

Workup

  1. customthat described in Preparation 49

Sources & evidence

ORD record
ord-86ab7a0938d343aab6ae7e7b4b46efca
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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