Triethylamine → 2-(p-Fluoroanilino)thiazole-4-carbaldehyde

HRID 2107275Notes

Reaction equation

HRID 2107275 reaction equation
[F:1][C:2]1[CH:15]=[CH:14][C:5]([NH:6][C:7]2[S:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=2)=[CH:4][CH:3]=1.C(N(CC)CC)C>CS(C)=O>[F:1][C:2]1[CH:15]=[CH:14][C:5]([NH:6][C:7]2[S:8][CH:9]=[C:10]([CH:12]=[O:13])[N:11]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 150535552-p-Fluoroanilinothiazol-4-ylmethanol

Product 1

HCID 150535722-(p-Fluoroanilino)thiazole-4-carbaldehyde

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The reaction described in Preparation 44 was repeated, but using 3.03 g of 2-p-fluoroanilinothiazol-4-ylmethanol, 8.5 g of pyridine sulfur trioxide complex, 7.5 ml of triethylamine and 140 ml of dimethyl sulfoxide. giving the title compound as pale brown prisms.

Workup

  1. customThe reaction described in Preparation 44

Sources & evidence

ORD record
ord-866a9f38546e4b30bba6e3e0351639df
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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