Ethyl 2-(4-methoxyanilino)-1,3-thiazole-4-carboxylate → HCID 15053556, compound

HRID 2107276Notes

Reaction equation

HRID 2107276 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[S:11][CH:12]=[C:13]([C:15](OCC)=[O:16])[N:14]=2)=[CH:5][CH:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]2[S:11][CH:12]=[C:13]([CH2:15][OH:16])[N:14]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 2769692Ethyl 2-(4-methoxyanilino)-1,3-thiazole-4-carboxylateHCID 21226445Aluminium lithium hydride

Product 1

HCID 15053556HCID 15053556, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The reaction described in Preparation 15 was repeated, but using 5.0 g of ethyl 2-p-anisidinothiazole-4-carboxylate, 1 5 g of lithium aluminum hydride and 100 ml of anhydrous tetrahydrofuran, giving the title compound as a pale red powder.

Workup

  1. customThe reaction described in Preparation 15

Sources & evidence

ORD record
ord-b5e5859896084561b7a3e4396eaad98e
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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