Triethylamine → 2-Ethylaminothiazole-4-carbaldehyde

HRID 2107280Notes

Reaction equation

HRID 2107280 reaction equation
[CH2:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([CH2:9][OH:10])[N:8]=1)[CH3:2].C(N(CC)CC)C>CS(C)=O>[CH2:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([CH:9]=[O:10])[N:8]=1)[CH3:2]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 150535582-Ethylaminothiazol-4-ylmethanol

Product 1

HCID 150535752-Ethylaminothiazole-4-carbaldehyde

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The reaction described in Preparation 44 was repeated, but using 4.4 g of 2-ethylaminothiazol-4-ylmethanol, 13.3 g of sulfur trioxide pyridine complex, 8.4 g of triethylamine and 60 ml of dimethyl sulfoxide, giving the title compound as pale brown prisms.

Workup

  1. customThe reaction described in Preparation 44

Sources & evidence

ORD record
ord-c98c479b5be64173be73c1ae950b16fb
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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