Triethylamine → 2-Cyclohexylaminothiazole-4-carbaldehyde

HRID 2107286Notes

Reaction equation

HRID 2107286 reaction equation
[CH:1]1([NH:7][C:8]2[S:9][CH:10]=[C:11]([CH2:13][OH:14])[N:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C>CS(C)=O>[CH:1]1([NH:7][C:8]2[S:9][CH:10]=[C:11]([CH:13]=[O:14])[N:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 150535602-Cyclohexylaminothiazol-4-ylmethanol

Product 1

HCID 150535772-Cyclohexylaminothiazole-4-carbaldehyde

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The reaction described in Preparation 44 was repeated, but using 10 g of 2-cyclohexylaminothiazol-4-ylmethanol, 22.4 g of sulfur trioxide pyridine complex, 14.3 g of triethylamine and 100 ml of dimethyl sulfoxide, giving the title compound as a pale brown oil.

Workup

  1. customThe reaction described in Preparation 44

Sources & evidence

ORD record
ord-439cffc706314df7814634ffac8a5f0a
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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