Ethyl 2-(piperidin-1-yl)-1,3-thiazole-4-carboxylate → HCID 15053562, compound

HRID 2107292Notes

Reaction equation

HRID 2107292 reaction equation
[N:1]1([C:7]2[S:8][CH:9]=[C:10]([C:12](OCC)=[O:13])[N:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[N:1]1([C:7]2[S:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 15053545Ethyl 2-(piperidin-1-yl)-1,3-thiazole-4-carboxylateHCID 21226445Aluminium lithium hydride

Product 1

HCID 15053562HCID 15053562, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The reaction described in Preparation 15 was repeated, but using 3.0 g of ethyl 2-piperidinothiazole-4-carboxylate, 0.5 g of lithium aluminum hydride and 50 ml of tetrahydrofuran, giving the title compound as pale yellow prisms.

Workup

  1. customThe reaction described in Preparation 15

Sources & evidence

ORD record
ord-e4fee18126994ebf940ec98b9fba1d5f
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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