Ethyl bromopyruvate → Ethyl 2-isopropylaminothiazole-4-carboxylate

HRID 2107302Notes

Reaction equation

HRID 2107302 reaction equation
[CH:1]([NH:4][C:5]([NH2:7])=[S:6])([CH3:3])[CH3:2].Br[CH2:9][C:10](=O)[C:11]([O:13][CH2:14][CH3:15])=[O:12]>C(O)C>[CH:1]([NH:4][C:5]1[S:6][CH:9]=[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:7]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 66144Ethyl bromopyruvateHCID 1711921Urea, 1-isopropyl-2-thio-

Product 1

HCID 15053549Ethyl 2-isopropylaminothiazole-4-carboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The reaction described in Preparation 42 was repeated, but using 3.7 g of isopropylthiourea, 7.4 g of ethyl bromopyruvate and 50 ml of ethanol, giving the title compound as a pale yellow oil.

Workup

  1. customThe reaction described in Preparation 42

Sources & evidence

ORD record
ord-975a0b793e334788b6c424fd96bd50b6
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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