126534-13-2 → 2-[(Phenylmethyl)amino]-4-thiazolemethanol

HRID 2107305Notes

Reaction equation

HRID 2107305 reaction equation
[CH2:1]([NH:8][C:9]1[S:10][CH:11]=[C:12]([C:14](OCC)=[O:15])[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:1]([NH:8][C:9]1[S:10][CH:11]=[C:12]([CH2:14][OH:15])[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 15053550126534-13-2HCID 21226445Aluminium lithium hydride

Product 1

HCID 150535672-[(Phenylmethyl)amino]-4-thiazolemethanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The reaction described in Preparation 15 was repeated, but using 5 g of ethyl 2-benzylaminothiazole-4-carboxylate, 1.4 g of lithium aluminum hydride and 100 ml of tetrahydrofuran, giving the title compound as colorless needles.

Workup

  1. customThe reaction described in Preparation 15

Sources & evidence

ORD record
ord-a4c3f776c52c4ee1bb7eca39acec763a
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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