2-[(Phenylmethyl)amino]-4-thiazolemethanol → HCID 15053585, compound

HRID 2107306Notes

Reaction equation

HRID 2107306 reaction equation
[CH2:1]([NH:8][C:9]1[S:10][CH:11]=[C:12]([CH2:14][OH:15])[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(N(CC)CC)C>[CH2:1]([NH:8][C:9]1[S:10][CH:11]=[C:12]([CH:14]=[O:15])[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 150535672-[(Phenylmethyl)amino]-4-thiazolemethanol

Product 1

HCID 15053585HCID 15053585, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The reaction described in Preparation 44 was repeated, but using 1.21 g of 2-benzylaminothiazol-4-ylmethanol, 2.6 g of pyridine sulfur trioxide complex, 3 ml of triethylamine and 30 ml of dimethyl sulfoxlde, giving the title compound as pale brown crystals.

Workup

  1. customThe reaction described in Preparation 44

Sources & evidence

ORD record
ord-bc0e3913e73f4b8993a4f8e9407df574
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

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