Cyclopropylamine → HCID 15053551, compound

HRID 2107307Notes

Reaction equation

HRID 2107307 reaction equation
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.Br[C:6]1[S:7][CH:8]=[C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:10]=1>C1(C)C=CC=CC=1>[CH:1]1([NH:4][C:6]2[S:7][CH:8]=[C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:10]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 353965Ethyl 2-bromo-1,3-thiazole-4-carboxylate

Product 1

HCID 15053551HCID 15053551, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The reaction described in Preparation 26 was repeated, except that a mixture comprising 2.28 g of cyclopropylamine, 5.0 g of ethyl 2-bromothiazole-4-carboxylate and 20 ml of toluene was heated at 100°-110 ° C. for 16 hours in a sealed tube, giving the title compound as a pale yellow oil.

Workup

  1. customThe reaction described in Preparation 26
  2. temperaturewas heated at 100°-110 ° C. for 16 hours in a sealed tube

Sources & evidence

ORD record
ord-8c672ab097c242b4980545ce709da6e2
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Reaction notes

Loading…