Thionyl Chloride → HCID 14405369, compound

HRID 2107528Notes

Reaction equation

HRID 2107528 reaction equation
[F:1][CH:2]([F:18])[O:3][C:4]1[CH:17]=[CH:16][C:7]([CH:8](O)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=1.S(Cl)([Cl:21])=O>C(Cl)(Cl)Cl>[F:1][CH:2]([F:18])[O:3][C:4]1[CH:17]=[CH:16][C:7]([CH:8]([Cl:21])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 14405368HCID 14405368, compound

Product 1

HCID 14405369HCID 14405369, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Conditions

Temperature
0 °C

Procedure

55 g of 4-difluoromethoxybenzhydrol are dissolved in 440 ml of chloroform, the mixture is cooled to 0° C. and 17.5 ml of thionyl chloride in 220 ml of chloroform are added. The mixture is allowed to stand for 24 hours at room temperature and excess thionyl chloride and chloroform are removed by distillation. 47 g (80%) of 4-difluoromethoxybenzhydryl chloride are obtained as a yellow oil.

Workup

  1. customexcess thionyl chloride and chloroform are removed by distillation

Sources & evidence

ORD record
ord-bfd17e8cadbc470a9b6c70c76719e03d
Source dataset
uspto-grants-1990_06
Patent number
US04935414

Reaction notes

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