[4-(difluoromethoxy)phenyl](phenyl)methanone → HCID 14405368, compound

HRID 2107529Notes

Reaction equation

HRID 2107529 reaction equation
[F:1][CH:2]([F:18])[O:3][C:4]1[CH:17]=[CH:16][C:7]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=1.[BH4-].[Na+]>CO>[F:1][CH:2]([F:18])[O:3][C:4]1[CH:5]=[CH:6][C:7]([CH:8]([OH:9])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 3315228[4-(difluoromethoxy)phenyl](phenyl)methanoneHCID 4311764Sodium borohydride

Product 1

HCID 14405368HCID 14405368, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

60 g of 4-difluoromethoxybenzophenone are reduced using sodium borohydride in 400 ml of methanol at 40° C. After an hour, the mixture is concentrated to dryness, 1.2 l of water is added to the contents of the flask and the mixture is extracted with chloroform. The organic phase is then dried and concentrated.

Workup

  1. customat 40° C
  2. waitAfter an hour
  3. concentrationthe mixture is concentrated to dryness, 1.2 l of water
  4. additionis added to the contents of the flask
  5. extractionthe mixture is extracted with chloroform
  6. customThe organic phase is then dried
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-d3fc4c1643d94a6b97eafb5b331257b0
Source dataset
uspto-grants-1990_06
Patent number
US04935414

Reaction notes

Loading…