Chloroform → HCID 14817914, compound

HRID 2107552Notes

Reaction equation

HRID 2107552 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.C(Cl)(Cl)Cl.[C:20]([N:25]=[C:26]=[O:27])(=[O:24])[C:21]([CH3:23])=[CH2:22]>ClCCCl>[C:20]([NH:25][C:26](=[O:27])[O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:7]=1)(=[O:24])[C:21]([CH3:23])=[CH2:22]

Participants

5

Reactant 3

HCID 6212ChloroformHCID 143474-HydroxybenzophenoneHCID 10942374Methacryloyl isocyanate

Product 1

HCID 14817914HCID 14817914, compoundYield 100.2%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

Into a three-necked flask purged with nitrogen gas, p-hydroxybenzophenone (1.98 g; 10 mmol) was charged, and chloroform (10 ml) was added thereto. To the resultant solution, a solution of methacryloyl isocyanate (1.11 g; 10 mmol) in 1,2-dichloroethane (5 ml) was dropwise added in 5 minutes under nitrogen stream while stirring. Chloroform and 1,2-dichloroethane were removed by evaporation under reduced pressure to give p-benzoylphenyl N-methacryloylcarbamate (3.1 g), which was recrysallized from a mixture of benzene and chloroform to give white granules. M.P., 96°-97° C.

Workup

  1. additionwas charged
  2. customChloroform and 1,2-dichloroethane were removed by evaporation under reduced pressure

Sources & evidence

ORD record
ord-bfab171829a64983845376997fb4894a
Source dataset
uspto-grants-1990_06
Patent number
US04935413

Reaction notes

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