1-(4-tert-Butylphenyl)piperazine → N-(4-Tert-butylcyclohexyl)-piperazine

HRID 2107611Notes

Reaction equation

HRID 2107611 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>O1CCOCC1.[Ru](=O)=O>[C:1]([CH:5]1[CH2:6][CH2:7][CH:8]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH2:9][CH2:10]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 7817221-(4-tert-Butylphenyl)piperazine

Product 1

HCID 14553997N-(4-Tert-butylcyclohexyl)-piperazine

Reagents, catalysts & solvents 2

HCID 82848Ruthenium dioxideCatalystHCID 312751,4-DioxaneSolvent

Procedure

90 g (0.41 mole) of N-(4-tert-butylphenyl)-piperazine in 1.6 l of dioxane are hydrogenated over 5 g of ruthenium(IV) oxide at 130° C. and under 150 bar for 74 hours. Working up in the usual manner gives a white solid.

Workup

  1. customWorking up in the usual manner gives a white solid

Sources & evidence

ORD record
ord-61024e96bc7a4bee913b9825fccb67c9
Source dataset
uspto-grants-1990_06
Patent number
US04935426

Reaction notes

Loading…