反应详情

5.0 g (22.3 millimoles) of N-(4-tert-butylcyclohexyl)-piperazine, 5.4 g (44.6 millimoles) of 3,3-dimethylcyclohexanone, 1.7 g (12.3 millimoles) of zinc(II) chloride and 1.6 g (24.5 millimoles) of sodium cyanoborohydride are stirred for 48 hours at 20° C. The mixture is evaporated down under reduced pressure, the residue is hydrolyzed with 1N sodium hydroxide solution and the mixture is extracted with methyl tert-butyl ether. Working up the organic extract in the usual manner gives 3.7 g (50% of theory) of a product in the form of white crystals (mp. 90°-92° C.; for IR data, see Table 1b).

1. customThe mixture is evaporated down under reduced pressure
2. extractionthe mixture is extracted with methyl tert-butyl ether
3. extractionWorking up the organic extract in the usual manner
4. customgives 3.7 g (50% of theory) of a product in the form of white crystals (mp. 90°-92° C.; for IR data, see Table 1b)