反应详情

5 g (22.9 millimoles) of N-(4-tert-butylphenyl)-piperazine, 8.3 g (68.7 millimoles) of neohexyl chloride, 3.2 g (22.9 millimoles) of potassium carbonate and 3.8 g (22.9 millimoles) of potassium iodide are stirred for 16 hours at 140° C. The mixture is taken up in dichloromethane and dilute sodium hydroxide solution. The organic phase is washed, dried over sodium sulfate and evaporated down under reduced pressure, and the residue is chromatographed over silica gel using 1:1 methyl tert-butyl ether/hexane to give 1.5 g (22% of theory) of a colourless oil (for IR data, see Table 1a).

1. washThe organic phase is washed
2. dry with materialdried over sodium sulfate
3. customevaporated down under reduced pressure
4. customthe residue is chromatographed over silica gel using 1:1 methyl tert-butyl ether/hexane
5. customto give 1.5 g (22% of theory) of a colourless oil (for IR data, see Table 1a)