反应详情

Methyl 4-methoxy-3-thiophenecarboxylate (50.8 g, 0.295 mol) was refluxed with hydrazine hydrate (30 ml) in methanol (250 ml) overnight. The solvent was evaporated and the residue was diluted with water (300 ml) and extracted with dichloromethane (5×100 ml). The dichloromethane extracts were dried over sodium sulfate, filtered and evaporated under reduced pressure to give the title compound as an off white solid, 49.5 g, m.p. 91°-92°.

1. customThe solvent was evaporated
2. additionthe residue was diluted with water (300 ml)
3. extractionextracted with dichloromethane (5×100 ml)
4. dry with materialThe dichloromethane extracts were dried over sodium sulfate
5. filtrationfiltered
6. customevaporated under reduced pressure