反应详情

4-Methoxy-3-thiopheneamine (11.8 g, 0.091 mol) and diethyl ethoxymethylenemalonate (19.75 g, 0.091 mol) in toluene (300 ml) was heated under reflux in an atmosphere of nitrogen for 18 hours. The solvent was evaporated under reduced pressure to give a buff-coloured solid, this was washed with petroleum ether (b.p. 40°-60°) and the title compound collected by filtration, 25.23 g, m.p. 100°-102°.

1. temperatureunder reflux in an atmosphere of nitrogen for 18 hours
2. customThe solvent was evaporated under reduced pressure
3. customto give a buff-coloured solid
4. washthis was washed with petroleum ether (b.p. 40°-60°)
5. filtrationthe title compound collected by filtration, 25.23 g, m.p. 100°-102°