反应详情

To a refluxing solution of diphenyl ether (250 ml) was added ethyl 2-ethoxycarbonyl-3-(4-methoxy-3-thienylamino)prop-2-enoate (25 g, 0.0836 mol) portionwise. On completion of the addition, refluxing was continued for a further 20 minutes. The reaction mixture was allowed to cool and then diluted with petroleum ether (b.p. 40°-60°) (400 ml) to give a dark brown solid. This was collected by filtration, washed with petroleum-ether (b.p. 40°-60°) (100 ml) and dried. The solid was recrystallized from DMF (30 ml) to give the title compound as a pale purple solid, 12.7 g, m.p. 244°-247°.

1. additionOn completion of the addition
2. temperaturerefluxing
3. temperatureto cool
4. customto give a dark brown solid
5. filtrationThis was collected by filtration
6. washwashed with petroleum-ether (b.p. 40°-60°) (100 ml)
7. customdried
8. customThe solid was recrystallized from DMF (30 ml)