反应详情

3-Methoxy-6-ethoxycarbonylthieno[3,2-b]pyridin-7-(4H)-one (3 g, 0.0118 mol) and phosphorus oxychloride (10 ml) was heated under reflux for one hour. The reaction mixture was poured onto ice (200 g) and stirred for 30 minutes. The mixture was then basified with 40% sodium hydroxide solution and extracted with chloroform (3×100 ml). The chloroform extracts were combined, dried over magnesium sulphate, filtered and evaporated under reduced pressure to give the title compound as a buff-colour solid, 3.2 g, m.p. 135°-137°.

1. temperatureunder reflux for one hour
2. additionThe reaction mixture was poured onto ice (200 g)
3. extractionextracted with chloroform (3×100 ml)
4. dry with materialdried over magnesium sulphate
5. filtrationfiltered
6. customevaporated under reduced pressure