Ethyl 2-butyryl-3-ethoxyacrylate → ethyl 2-[[(4-methoxythiophen-3-yl)amino]methylidene]-3-oxohexanoate

HRID 2107626Notes

Reaction equation

HRID 2107626 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH2:8])=[CH:5][S:6][CH:7]=1.[C:9]([C:14](=[CH:20]OCC)[C:15]([O:17][CH2:18][CH3:19])=[O:16])(=[O:13])[CH2:10][CH2:11][CH3:12]>>[C:9]([C:14](=[CH:20][NH:8][C:4]1[C:3]([O:2][CH3:1])=[CH:7][S:6][CH:5]=1)[C:15]([O:17][CH2:18][CH3:19])=[O:16])(=[O:13])[CH2:10][CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 3359484Ethyl 2-butyryl-3-ethoxyacrylateHCID 149896854-Methoxythiophen-3-amine

Product 1

HCID 178450504ethyl 2-[[(4-methoxythiophen-3-yl)amino]methylidene]-3-oxohexanoate

Procedure

4-Methoxy-3-thiopheneamine (11 g, 0.085 mol) and ethyl 2-butyryl-3-ethoxyprop-2-enoate (20 g, 0.093 mol) was heated in an inert atmosphere at 120° for 30 minutes. Addition of petroleum ether, b.p. 40°-60°, 200 ml, gave a solid which was collected by filtration and dried, 17.58 g, m.p. 89°-91°.

Workup

  1. customgave a solid which
  2. filtrationwas collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-13e10781fd984666a98a8ff8db638f61
Source dataset
uspto-grants-1990_06
Patent number
US04935431

Reaction notes

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