ethyl 2-[[(4-methoxythiophen-3-yl)amino]methylidene]-3-oxohexanoate → 3-Methoxy-6-butyrylthieno[3,2-b]pyridin-7(4H)-one

Participants

Reaction Steps

To a refluxing solution of diphenyl ether (200 ml) was added ethyl 2-butyryl-3-(4-methoxy-3-thienylamino)-prop-2-enoate (16 g, 0.0539 mol) portionwise. On completion of the addition refluxing was continued for a further 20 minutes. The reaction mixture was allowed to cool and then diluted with petroleum ether to give a pale yellow solid, 11.85 g, m.p. 222°-225°.

Provenance & Evidence