Dimethylformamide → HCID 86744038, compound

HRID 2107781Notes

Reaction equation

HRID 2107781 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:16]([CH3:20])([CH3:19])[C:17]#[N:18])[C:5]([CH2:13]C#N)=[C:6]([C:8]([CH3:12])([CH3:11])[C:9]#[N:10])[CH:7]=1.[NH:21]1[CH:25]=[N:24][CH:23]=[N:22]1.[CH3:26][N:27](C)C=O>O>[C:26]([C:2]1[CH:3]=[C:4]([C:16]([CH3:20])([CH3:19])[C:17]#[N:18])[C:5]([CH2:13][N:21]2[CH:25]=[N:24][CH:23]=[N:22]2)=[C:6]([C:8]([CH3:11])([CH3:12])[C:9]#[N:10])[CH:7]=1)#[N:27]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 92571H-1,2,4-TriazoleHCID 19349433HCID 19349433, compound

Product 1

HCID 86744038HCID 86744038, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2,2'-[5-bromocyanomethyl-1,3-phenylene]di(2-methylpropiononitrile) (0.33 g), 1,2,4-triazole (0.34 g) and dimethylformamide (2 ml) was stirred at 50° for 24 h. The mixture was treated with water (20 ml), and extracted with ethyl acetate, and the extract was dried and evaporated to dryness under reduced pressure. The residue was purified by flash chromatography, using methanol (3% by volume) in dichloromethane as eluant, to give 2,2'-[5-cyano(1H-1,2,4-triazol-1-yl)methyl-1,3-phenylene]di(2-methylpropiono-nitrile), characterised as the hydrochloride salt, mp 148°-151°.

Workup

  1. extractionextracted with ethyl acetate
  2. customthe extract was dried
  3. customevaporated to dryness under reduced pressure
  4. customThe residue was purified by flash chromatography

Sources & evidence

ORD record
ord-be510770424748eab902e0c29e448c7e
Source dataset
uspto-grants-1990_06
Patent number
US04935437

Reaction notes

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