Hydrochloric Acid → Methyl 4-AMino-5-chloro-2-Methoxybenzoate

HRID 2107787Notes

Reaction equation

HRID 2107787 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([NH2:12])[C:9]([Cl:13])=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].Cl.[CH3:15]O>>[ClH:13].[CH3:1][O:2][C:3]1[CH:11]=[C:10]([NH2:12])[C:9]([Cl:13])=[CH:8][C:4]=1[C:5]([O:7][CH3:15])=[O:6]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 816264-Amino-5-chloro-2-methoxybenzoic acid

Product 1

HCID 23046717Methyl 4-AMino-5-chloro-2-Methoxybenzoate

Procedure

A suspension of 30 g (0.15 mol) of 2-methoxy-4-amino-5-chlorobenzoic acid in 500 ml methanol is cooled to 0° and the mixture treated with gaseous HCl for 30 minutes. After all the acid dissolves the solution is evaporated to dryness to obtain methyl 2-methoxy-4-amino-5-chlorobenzoate hydrochloride which is used directly in the next step.

Workup

  1. temperatureis cooled to 0°
  2. dissolutionAfter all the acid dissolves the solution
  3. customis evaporated to dryness

Sources & evidence

ORD record
ord-786e7d1f6477468e9f8f88dd6b185843
Source dataset
uspto-grants-1990_06
Patent number
US04935511

Reaction notes

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