Methanol → HCID 23046753, compound

HRID 2107789Notes

Reaction equation

HRID 2107789 reaction equation
S(Cl)([Cl:3])=O.[NH2:5][C:6]1[CH:7]=[C:8]([OH:16])[C:9](=[CH:13][C:14]=1[Cl:15])[C:10]([OH:12])=[O:11].[CH3:17]O>>[ClH:3].[NH2:5][C:6]1[CH:7]=[C:8]([OH:16])[C:9](=[CH:13][C:14]=1[Cl:15])[C:10]([O:12][CH3:17])=[O:11]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 148832224-Amino-5-chloro-2-hydroxybenzoic acid

Product 1

HCID 23046753HCID 23046753, compound

Conditions

Temperature
0 °C

Procedure

To 300 ml of methanol is added 30 ml of thionylchloride and stirred at 0° C. To this is added 26 g (0.14 mol) of 4-amino-5-chlorosalicylic acid and refluxed for 18 hours. The mixture is clear and evaporated to dryness to obtain methyl 4-amino-5-chlorosalicylate hydrochloride which is then used directly in the next step.

Workup

  1. temperaturerefluxed for 18 hours
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-3b97b4a0905d4ab38c42594ba281936b
Source dataset
uspto-grants-1990_06
Patent number
US04935511

Reaction notes

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