反应详情

温度

0 °C

To 300 ml of methanol is added 30 ml of thionylchloride and stirred at 0° C. To this is added 26 g (0.14 mol) of 4-amino-5-chlorosalicylic acid and refluxed for 18 hours. The mixture is clear and evaporated to dryness to obtain methyl 4-amino-5-chlorosalicylate hydrochloride which is then used directly in the next step.

1. temperaturerefluxed for 18 hours
2. customevaporated to dryness