Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Amino-5-chloro-2-hydroxybenzoic acid | HCID 14883222 | — |
| Product | HCID 23046753 | HCID 23046753 | — |
Reaction Steps
To 300 ml of methanol is added 30 ml of thionylchloride and stirred at 0° C. To this is added 26 g (0.14 mol) of 4-amino-5-chlorosalicylic acid and refluxed for 18 hours. The mixture is clear and evaporated to dryness to obtain methyl 4-amino-5-chlorosalicylate hydrochloride which is then used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04935511 |
|---|
| Source dataset | uspto-grants-1990_06 |
|---|
| ORD ID | ord-3b97b4a0905d4ab38c42594ba281936b |
|---|
| Source note | uspto-grants-1990_06 |
|---|
