反应详情

温度

-10 °C

To a mixture of 90 ml concentrated HNO3 and 10 ml concentrated H2SO4 cooled to -10° C. is added portionwise over 5 minutes 10.9 g (38.2 mmol) methyl 2-acetoxy-4-acetylamino-5-chlorobenzoate. The mixture is stirred another 5 minutes and poured into ice water (400 ml). The ppt. which forms is filtered, washed (H2O) and dried to obtain methyl 3-nitro-4-acetylamino-5-chlorosalicylate; m.p. 166°-69° C.

1. filtrationwhich forms is filtered
2. washwashed (H2O)
3. customdried