Nitric Acid → HCID 15125648, compound

HRID 2107791Notes

Reaction equation

HRID 2107791 reaction equation
[N+:1]([O-:4])(O)=[O:2].OS(O)(=O)=O.C([O:13][C:14]1[CH:23]=[C:22]([NH:24][C:25](=[O:27])[CH3:26])[C:21]([Cl:28])=[CH:20][C:15]=1[C:16]([O:18][CH3:19])=[O:17])(=O)C>>[N+:1]([C:23]1[C:22]([NH:24][C:25](=[O:27])[CH3:26])=[C:21]([Cl:28])[CH:20]=[C:15]([C:16]([O:18][CH3:19])=[O:17])[C:14]=1[OH:13])([O-:4])=[O:2]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 15125647HCID 15125647, compound

Product 1

HCID 15125648HCID 15125648, compound

Conditions

Temperature
-10 °C

Procedure

To a mixture of 90 ml concentrated HNO3 and 10 ml concentrated H2SO4 cooled to -10° C. is added portionwise over 5 minutes 10.9 g (38.2 mmol) methyl 2-acetoxy-4-acetylamino-5-chlorobenzoate. The mixture is stirred another 5 minutes and poured into ice water (400 ml). The ppt. which forms is filtered, washed (H2O) and dried to obtain methyl 3-nitro-4-acetylamino-5-chlorosalicylate; m.p. 166°-69° C.

Workup

  1. filtrationwhich forms is filtered
  2. washwashed (H2O)
  3. customdried

Sources & evidence

ORD record
ord-bc62d50c8f89450a8e013fd882be5e8b
Source dataset
uspto-grants-1990_06
Patent number
US04935511

Reaction notes

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