Nitric Acid → HCID 15125648, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 90 ml concentrated HNO3 and 10 ml concentrated H2SO4 cooled to -10° C. is added portionwise over 5 minutes 10.9 g (38.2 mmol) methyl 2-acetoxy-4-acetylamino-5-chlorobenzoate. The mixture is stirred another 5 minutes and poured into ice water (400 ml). The ppt. which forms is filtered, washed (H2O) and dried to obtain methyl 3-nitro-4-acetylamino-5-chlorosalicylate; m.p. 166°-69° C.

Provenance & Evidence