Hydrochloric Acid → HCID 15125649, compound

Participants

Reaction Conditions

Reaction Steps

Sodium (3.8 g, 0.17 m) is dissolved in 150 ml methanol and to this is added methyl 3-nitro-4-acetylamino-5-chlorosalicylate (5 g, 17 mmol) under nitrogen. This mixture is then heated to reflux overnight. The mixture is then cooled to 20° C. and poured into a rapidly stirring mixture of ice and 10% HCl (650 ml). The ppt. which forms is filtered, washed with H2O and dried to obtain methyl 3-nitro-4-amino-5-chlorosalicylate as a yellow powder which is used directly in the next step.

Provenance & Evidence