反应详情

温度

20 °C

Sodium (3.8 g, 0.17 m) is dissolved in 150 ml methanol and to this is added methyl 3-nitro-4-acetylamino-5-chlorosalicylate (5 g, 17 mmol) under nitrogen. This mixture is then heated to reflux overnight. The mixture is then cooled to 20° C. and poured into a rapidly stirring mixture of ice and 10% HCl (650 ml). The ppt. which forms is filtered, washed with H2O and dried to obtain methyl 3-nitro-4-amino-5-chlorosalicylate as a yellow powder which is used directly in the next step.

1. temperatureThis mixture is then heated
2. temperatureto reflux overnight
3. additionpoured into
4. filtrationwhich forms is filtered
5. washwashed with H2O
6. customdried