HCID 15125649, compound → HCID 15125650, compound

Participants

Reaction Steps

Methyl 3-nitro-4-amino-5-chlorosalicylate (4.1 g, 0.017 mmol) is hydrogenated at 45 initial psi in 450 ml ethanol for 30 minutes using 2.1 g of 10% Pt/C. The catalyst is then filtered (celite) and washed with ethylacetate (450 ml) and the filtrate evaporated in vacuo to give methyl 3,4-diamino-5-chlorosalicylate which is used directly in the next step.

Provenance & Evidence