反应详情

Methyl 3-nitro-4-amino-5-chlorosalicylate (4.1 g, 0.017 mmol) is hydrogenated at 45 initial psi in 450 ml ethanol for 30 minutes using 2.1 g of 10% Pt/C. The catalyst is then filtered (celite) and washed with ethylacetate (450 ml) and the filtrate evaporated in vacuo to give methyl 3,4-diamino-5-chlorosalicylate which is used directly in the next step.

1. customfor 30 minutes
2. filtrationThe catalyst is then filtered (celite)
3. washwashed with ethylacetate (450 ml)
4. customthe filtrate evaporated in vacuo