HCID 15125649, compound → HCID 15125650, compound

HRID 2107793Notes

Reaction equation

HRID 2107793 reaction equation
[N+:1]([C:4]1[C:13]([NH2:14])=[C:12]([Cl:15])[CH:11]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[C:5]=1[OH:16])([O-])=O>C(O)C.[Pt]>[NH2:1][C:4]1[C:13]([NH2:14])=[C:12]([Cl:15])[CH:11]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[C:5]=1[OH:16]

Participants

4

Reactant 1

HCID 15125649HCID 15125649, compound

Product 1

HCID 15125650HCID 15125650, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 702EthanolSolvent

Procedure

Methyl 3-nitro-4-amino-5-chlorosalicylate (4.1 g, 0.017 mmol) is hydrogenated at 45 initial psi in 450 ml ethanol for 30 minutes using 2.1 g of 10% Pt/C. The catalyst is then filtered (celite) and washed with ethylacetate (450 ml) and the filtrate evaporated in vacuo to give methyl 3,4-diamino-5-chlorosalicylate which is used directly in the next step.

Workup

  1. customfor 30 minutes
  2. filtrationThe catalyst is then filtered (celite)
  3. washwashed with ethylacetate (450 ml)
  4. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-a3afcad5a09b4f819de1a5fb49fd8b2e
Source dataset
uspto-grants-1990_06
Patent number
US04935511

Reaction notes

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