Hydrochloric Acid → HCID 18631391, compound

HRID 2107867Notes

Reaction equation

HRID 2107867 reaction equation
C(OC([NH:8][C@@H:9]([CH2:21][CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)[C@@H:10]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:11][OH:12])=O)(C)(C)C.Cl>CCOCC>[NH2:8][C@@H:9]([CH2:21][CH:22]1[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1)[C@@H:10]([O:13][CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[CH2:11][OH:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13882367HCID 13882367, compound

Product 1

HCID 18631391HCID 18631391, compoundYield 110.9%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
0 °C

Procedure

3(S)-t-Butoxycarbonylamino-2(R)-benzyloxy-4-cyclohexyl-1-butanol (108 mg) (U.S. Pat. No. 4,668,769), Example 1J was dissolved in 0.5 mL ether and cooled to 0° C. Into this solution was introduced excess anhydrous HCl and the solution was stirred at 25° C. for 2 hours and concentrated giving 88 mg of colorless solid, TLC Rf 0.28 in System A.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-d8bdea0a316a4dc8ad8e63ec35696791
Source dataset
uspto-grants-1990_06
Patent number
US04935405

Reaction notes

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