Acetic Anhydride → HCID 14421351, compound

HRID 2107877Notes

Reaction equation

HRID 2107877 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[N:13]([C:14]2[C:19]([F:20])=[CH:18][C:17]([C:21]([F:24])([F:23])[F:22])=[CH:16][C:15]=2[Cl:25])[N:12]=[CH:11][CH:10]=1>C(O)(=O)C>[C:5]([NH:8][C:9]1[N:13]([C:14]2[C:19]([F:20])=[CH:18][C:17]([C:21]([F:22])([F:24])[F:23])=[CH:16][C:15]=2[Cl:25])[N:12]=[CH:11][CH:10]=1)(=[O:7])[CH3:6]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 13913427HCID 13913427, compound

Product 1

HCID 14421351HCID 14421351, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3.7 ml (0.038 mol) of acetic anhydride are added to 100 g (0.036 mol) of 5-amino-1-(2-chloro-6-fluoro-4-trifluoromethylphenyl)-pyrazole in 60 ml of glacial acetic acid, and the mixture is stirred at room temperature for 9 hours. For working-up, the reaction mixture is added dropwise to 300 ml of ice-water, and the precipitate formed is filtered off, washed with water and dried in vacuo at 50° C. 8.9 g (77% of theory) of 5-acetamido-1-(2-chloro-6-fluoro-4-trifluoromethylphenyl)-pyrazole of melting point 144°-146° C. are obtained.

Workup

  1. customthe precipitate formed
  2. filtrationis filtered off
  3. washwashed with water
  4. customdried in vacuo at 50° C

Sources & evidence

ORD record
ord-0f3905e938974f5fb49e1afdc74e7b07
Source dataset
uspto-grants-1990_06
Patent number
US04936892

Reaction notes

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