Acetic Anhydride → HCID 14421351, compound

Participants

Reaction Steps

3.7 ml (0.038 mol) of acetic anhydride are added to 100 g (0.036 mol) of 5-amino-1-(2-chloro-6-fluoro-4-trifluoromethylphenyl)-pyrazole in 60 ml of glacial acetic acid, and the mixture is stirred at room temperature for 9 hours. For working-up, the reaction mixture is added dropwise to 300 ml of ice-water, and the precipitate formed is filtered off, washed with water and dried in vacuo at 50° C. 8.9 g (77% of theory) of 5-acetamido-1-(2-chloro-6-fluoro-4-trifluoromethylphenyl)-pyrazole of melting point 144°-146° C. are obtained.

Provenance & Evidence