Ethanol → HCID 73867402, compound

HRID 2107900Notes

Reaction equation

HRID 2107900 reaction equation
CC[CH2:3][C:4]([O:6][C:7]([CH2:9][CH2:10][CH3:11])=[O:8])=O.[CH2:12](O)[CH3:13].[CH2:15]([NH2:17])C>O>[CH3:15][NH:17][C:10]([CH2:11][CH2:12][CH3:13])=[CH:9][C:7]([O:6][CH2:4][CH3:3])=[O:8]

Participants

5

Reactant 3

HCID 702EthanolHCID 6341EthylamineHCID 7798Butyric anhydride

Product 1

HCID 73867402HCID 73867402, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 31.64 g (0.2 mol) ethyl butyryl acetate and 5 ml. of ethanol is added dropwise over a period of 5 min. to a solution of 38.7 g (0.6 mol) ethylamine (70% in water) and 50 ml of water (exotherm from 28° C. to 33° C. observed). The mixture is stirred at room temperature for 18 hrs. and is extracted with three 100 ml portions of methylene dichloride (MDC). The methylene dichloride extract is dried over magnesium sulfate and concentrated in vacuo to afford 30.7 g (83% yield) of product, a colorless oil.

Workup

  1. extractionand is extracted with three 100 ml portions of methylene dichloride (MDC)
  2. extractionThe methylene dichloride extract
  3. dry with materialis dried over magnesium sulfate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-94a771a183594e1cb9da72c37dc68126
Source dataset
uspto-grants-1990_06
Patent number
US04936904

Reaction notes

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