Methanol → HCID 22159888, compound

HRID 2107925Notes

Reaction equation

HRID 2107925 reaction equation
C([C:3]1[C:4](=[O:28])[C:5]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[C:6]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)O[C:8]=1[C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1)C.CO.[CH3:31][NH2:32]>O.C(O)(=O)C>[CH3:31][N:32]1[C:8]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[CH:3][C:4](=[O:28])[C:5]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[C:6]1[C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1

Participants

6

Reactant 3

HCID 887MethanolHCID 6329MethylamineHCID 22159933HCID 22159933, compound

Product 1

HCID 22159888HCID 22159888, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent2×

Procedure

5.0 gms of ethyl 2,6-di(4'-chlorophenyl)-3-ethoxycarbonyl-pyr-4-one, 100 mls of methanol, 19 mls of 40% aqueous methylamine, 19 mls of water and 2.9 mls of glacial acetic acid were mixed and allowed to stand at room temperature for 3 hours. The mixture was poured into water and extracted with methylene chloride to provide 5 gms of crude ethyl 1-methyl-2,6-di(4-chlorophenyl)-4-oxonicotinate as a yellowish semi-solid.

Workup

  1. extractionextracted with methylene chloride

Sources & evidence

ORD record
ord-6b7f4bf0820d4166921210805af64ad9
Source dataset
uspto-grants-1990_06
Patent number
US04936904

Reaction notes

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