Hydrochloric Acid → 349U85

HRID 2107957Notes

Reaction equation

HRID 2107957 reaction equation
[N:1]1([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[NH:13][C:12](=[O:17])[CH:11]=[CH:10]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:18]>CO>[ClH:18].[N:1]1([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[NH:13][C:12](=[O:17])[CH:11]=[CH:10]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 164017116942-29-1

Product 1

HCID 164016349U85

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

6-Piperidinocarbostyril, 0.5 g (0.002 mole), was suspended in 15 mL methanol. Five mL ethanolic hydrogen chloride was added, and the mixture was digested in a steam bath for 15 minutes until part of the methanol was evaporated After cooling, filtration and washing with ethyl acetate, the resulting white crystals, 0.4 g, were recrystallized by dissolving in warm methanol and adding ethyl acetate. The yield was 0.4 g 6-piperidinocarbostyril hydrochloride; m.p. 298°-300° C.

Workup

  1. customwas evaporated
  2. temperatureAfter cooling
  3. filtrationfiltration
  4. washwashing with ethyl acetate
  5. customthe resulting white crystals, 0.4 g, were recrystallized
  6. dissolutionby dissolving in warm methanol
  7. additionadding ethyl acetate

Sources & evidence

ORD record
ord-8887d12fe5914c1b8c0ee7a0a2b2bc80
Source dataset
uspto-grants-1990_06
Patent number
US04937248

Reaction notes

Loading…