Propargyl bromide → HCID 23045087, compound

HRID 2108021Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][CH2:9][OH:10].[CH2:11](Br)[C:12]#[CH:13]>>[CH2:13]([O:10][CH2:9][CH2:8][CH2:7][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[C:12]#[CH:11]

Participants

Reactant 2

HCID 7842Propargyl bromide

HCID 72922Pyripropanol

Product 1

HCID 23045087HCID 23045087, compound

Procedure

From 2-pyridinepropanol (13.7 g) and propargyl bromide (80% solution in toluene, 12 ml), with a reaction time of 2 h. FCC eluting with hexane-ether (1:1) gave the title compound as an orange oil (9.0 g), t.l.c. (System B 80:20:1) Rf 0.15.

Workup

customwith a reaction time of 2 h
washFCC eluting with hexane-ether (1:1)

Sources & evidence

ORD record: ord-833aca8dc2da4ed79d1b419315306ce4
Source dataset: uspto-grants-1990_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04937251

Reaction notes

Loading…