1,6-Dibromohexane → HCID 23045054, compound

HRID 2108026Notes

Reaction equation

HRID 2108026 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][OH:11])=[N:6][CH:7]=1.[Br:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]Br>>[Br:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][O:11][CH2:10][CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 123681,6-DibromohexaneHCID 139797355-Bromo-2-pyridinepropanol

Product 1

HCID 23045054HCID 23045054, compoundYield 68.4%

Procedure

From 3-(5-bromo-2-pyridinyl)propanol (2 g) and 1,6-dibromohexane (6.77 g) with a reaction time of 3 h. FCC eluting with hexane→hexane:ether (100:0→90:10) gave the title compound as a yellow oil (2.4 g), t.l.c. (hexane:ether 9:1) Rf 0.08.

Workup

  1. customwith a reaction time of 3 h
  2. washFCC eluting with hexane→hexane:ether (100:0→90:10)

Sources & evidence

ORD record
ord-b533c398a9034640a35fab2f788bc499
Source dataset
uspto-grants-1990_06
Patent number
US04937251

Reaction notes

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