Sodium Hydroxide → HCID 15106953, compound

HRID 2108060Notes

Reaction equation

HRID 2108060 reaction equation
C([O:4][CH2:5][CH2:6][CH2:7][C:8]1[S:17][C:16]2[N:15]3[C:18]([CH3:21])=[N:19][N:20]=[C:14]3[CH:13]([CH3:22])[N:12]=[C:11]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[Cl:29])[C:10]=2[CH:9]=1)(=O)C.[OH-].[Na+]>CO>[Cl:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[C:11]1[C:10]2[CH:9]=[C:8]([CH2:7][CH2:6][CH2:5][OH:4])[S:17][C:16]=2[N:15]2[C:18]([CH3:21])=[N:19][N:20]=[C:14]2[CH:13]([CH3:22])[N:12]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15106952HCID 15106952, compound

Product 1

HCID 15106953HCID 15106953, compoundYield 94.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2 g of compound obtained in Example 1 in 40 ml of methanol is added one equivalent of 2 normal sodium hydroxide solution and stirred at room temperature for 2 hours. The methanol is distilled off under reduced pressure and the residue is dissolved in 50 ml of chloroform. The solution is washed with water and then dried over anhydrous magnesium sulfate. After separating by filtration, the filtrate is concentrated under reduced pressure to give 1.7 g of 4-(2-chlorophenyl)-2-(3-hydroxypropyl)-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine.

Workup

  1. distillationThe methanol is distilled off under reduced pressure
  2. dissolutionthe residue is dissolved in 50 ml of chloroform
  3. washThe solution is washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customAfter separating by filtration
  6. concentrationthe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-12261b3366e8479b9d673e3b9f82e668
Source dataset
uspto-grants-1990_06
Patent number
US04937240

Reaction notes

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