Sodium Hydroxide → HCID 15106953, compound

Participants

Reaction Steps

To a solution of 2 g of compound obtained in Example 1 in 40 ml of methanol is added one equivalent of 2 normal sodium hydroxide solution and stirred at room temperature for 2 hours. The methanol is distilled off under reduced pressure and the residue is dissolved in 50 ml of chloroform. The solution is washed with water and then dried over anhydrous magnesium sulfate. After separating by filtration, the filtrate is concentrated under reduced pressure to give 1.7 g of 4-(2-chlorophenyl)-2-(3-hydroxypropyl)-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine.

Provenance & Evidence