Benzylamine → HCID 23045290, compound

HRID 2108129Notes

Reaction equation

HRID 2108129 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1.[CH2:18]([NH2:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[N:14]1[CH:15]=[CH:16][CH:17]=[C:12]([O:11][CH2:10][CH2:9][O:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:25][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:13]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 230452653-[2-[(6-Bromohexyl)oxy]ethoxy]pyridine

Product 1

HCID 23045290HCID 23045290, compound

Procedure

A solution of 3-[[2-[(6-bromohexyl)oxy]ethyl]oxy]pyridine (2 g) and benzylamine (10 ml) was stirred at 140° under nitrogen for 3 h. The solution was partitioned between 8% sodium bicarbonate (100 ml) and ethylacetate (100 ml). The organic extract was dried and distilled to give the title compound (1.8 g) as an oil. T.l.c. (System B 80:20:1) Rf 0.54

Workup

  1. customThe solution was partitioned between 8% sodium bicarbonate (100 ml) and ethylacetate (100 ml)
  2. extractionThe organic extract
  3. customwas dried
  4. distillationdistilled

Sources & evidence

ORD record
ord-861d08ece5bb41368b39f417691c1854
Source dataset
uspto-grants-1990_06
Patent number
US04937268

Reaction notes

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