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HRID2108150

反应详情

EQUATION

反应方程式

HRID 2108150 的结构方程式

REACTANTS

反应物

2
反应SMILES：[Li+].[N-]=[N+]=[N-]
HCID88163

Lithium azide

LiN3

反应SMILES：Cc1cn2c(nc1=O)O[C@H]1C[C@H]2O[C@@H]1CO
HCID6915752

未命名化合物

PRODUCTS

产物

1
反应SMILES：Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
HCID35370

3'-Azido-3'-deoxythymidine

C10H13N5O4

收率 80%

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CC(=O)N(C)C
溶剂HCID31374

Dimethylacetamide

C4H9NO

CONDITIONS

反应条件

温度
130 °C

PROCEDURE

实验过程

2,3'-Anhydrothymidine (0.673 g, 3.0 mmol), lithium azide (0.4 g, 9.0 mmol) and N,N-dimethylacetamide (7.5 ml) were heated together with stirring at 130° C. for 16 hr. The products were then worked-up and chromatographed on silica gel to give 3'-azido-3'-deoxythymidine (0.64 g, 80%). identical to authentic material.

WORKUP

后处理

  1. customworked-up and chromatographed on silica gel